Does the calcium binding protein calretinin protect dopaminergic neurons against degeneration in Parkinson's disease?
Identifieur interne : 002445 ( Main/Exploration ); précédent : 002444; suivant : 002446Does the calcium binding protein calretinin protect dopaminergic neurons against degeneration in Parkinson's disease?
Auteurs : Annick Mouatt-Prigent [France] ; Yves Agid [France] ; Etienne C. Hirsch [France]Source :
- Brain Research [ 0006-8993 ] ; 1994.
English descriptors
Abstract
Parkinson's disease (PD) is characterized by a heterogeneous loss of dopaminergic neurons in the human mesencephalon affecting mainly the substantia nigra pars compacta (SNpc) and to a lesser extent the other dopaminergic cell groups. A rise in intracellular calcium concentrations represents one of the final events leading to nerve cell death. Calbindin D28k, a protein capable of buffering intracellular calcium concentrations is present in the dopaminergic neurons that are selectively preserved in PD but not in those that degenerate. To determine whether other calcium-binding proteins also represent putative protective factors of dopaminergic neurons in PD, we analyzed immunohistochemically the distribution of calretinin-containing (CR+) neurons, in the human mesencephalon of three control subjects and four patients with PD. No significant differences were observed between the number of CR+ neurons in the two subject groups. Sequential double immunostaining for calretinin and tyrosine hydroxylase showed a variable proportion of CR+ neurons among dopaminergic neurons: moderate co-localization was found in catecholaminergic cell group A8 and in the dorsal part of the ventral tegmental area (VTA) and low co-localization in the SNpc, the ventral part of the VTA and the central gray substance. This indicates that calretinin may only protect some dopaminergic neurons against degeneration in PD. Yet, in the SNpc a selective preservation of CR+ dopaminergic neurons was observed, suggesting a neuroprotective role in some dopaminergic cell groups only.
Url:
DOI: 10.1016/0006-8993(94)90511-8
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Does the calcium binding protein calretinin protect dopaminergic neurons against degeneration in Parkinson's disease?</title><author><name sortKey="Mouatt Prigent, Annick" sort="Mouatt Prigent, Annick" uniqKey="Mouatt Prigent A" first="Annick" last="Mouatt-Prigent">Annick Mouatt-Prigent</name></author><author><name sortKey="Agid, Yves" sort="Agid, Yves" uniqKey="Agid Y" first="Yves" last="Agid">Yves Agid</name><affiliation><country>France</country><placeName><settlement type="city">Paris</settlement><region type="region" nuts="2">Île-de-France</region></placeName><orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName></affiliation></author><author><name sortKey="Hirsch, Etienne C" sort="Hirsch, Etienne C" uniqKey="Hirsch E" first="Etienne C." last="Hirsch">Etienne C. Hirsch</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:28498A4DCDF24F2114BDDFAB7D43925455B0BFA8</idno><date when="1994" year="1994">1994</date><idno type="doi">10.1016/0006-8993(94)90511-8</idno><idno type="url">https://api.istex.fr/document/28498A4DCDF24F2114BDDFAB7D43925455B0BFA8/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">001E37</idno><idno type="wicri:Area/Main/Curation">001B51</idno><idno type="wicri:Area/Main/Exploration">002445</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Does the calcium binding protein calretinin protect dopaminergic neurons against degeneration in Parkinson's disease?</title><author><name sortKey="Mouatt Prigent, Annick" sort="Mouatt Prigent, Annick" uniqKey="Mouatt Prigent A" first="Annick" last="Mouatt-Prigent">Annick Mouatt-Prigent</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>INSERM U289, Hoˆpital de la Salpêtrière, 47 boulevard de l'Hoˆpital, 75013 Paris </wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris </settlement></placeName></affiliation></author><author><name sortKey="Agid, Yves" sort="Agid, Yves" uniqKey="Agid Y" first="Yves" last="Agid">Yves Agid</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>INSERM U289, Hoˆpital de la Salpêtrière, 47 boulevard de l'Hoˆpital, 75013 Paris </wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris </settlement></placeName><placeName><settlement type="city">Paris</settlement><region type="region" nuts="2">Île-de-France</region></placeName><orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName></affiliation></author><author><name sortKey="Hirsch, Etienne C" sort="Hirsch, Etienne C" uniqKey="Hirsch E" first="Etienne C." last="Hirsch">Etienne C. Hirsch</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>INSERM U289, Hoˆpital de la Salpêtrière, 47 boulevard de l'Hoˆpital, 75013 Paris </wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris </settlement></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Brain Research</title><title level="j" type="abbrev">BRES</title><idno type="ISSN">0006-8993</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1994">1994</date><biblScope unit="volume">668</biblScope><biblScope unit="issue">1–2</biblScope><biblScope unit="page" from="62">62</biblScope><biblScope unit="page" to="70">70</biblScope></imprint><idno type="ISSN">0006-8993</idno></series><idno type="istex">28498A4DCDF24F2114BDDFAB7D43925455B0BFA8</idno><idno type="DOI">10.1016/0006-8993(94)90511-8</idno><idno type="PII">0006-8993(94)90511-8</idno><idno type="ArticleID">94905118</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0006-8993</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Calcium binding protein</term><term>Human</term><term>Mesencephalon</term><term>Parkinson's disease</term><term>Tyrosine hydroxylase</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Parkinson's disease (PD) is characterized by a heterogeneous loss of dopaminergic neurons in the human mesencephalon affecting mainly the substantia nigra pars compacta (SNpc) and to a lesser extent the other dopaminergic cell groups. A rise in intracellular calcium concentrations represents one of the final events leading to nerve cell death. Calbindin D28k, a protein capable of buffering intracellular calcium concentrations is present in the dopaminergic neurons that are selectively preserved in PD but not in those that degenerate. To determine whether other calcium-binding proteins also represent putative protective factors of dopaminergic neurons in PD, we analyzed immunohistochemically the distribution of calretinin-containing (CR+) neurons, in the human mesencephalon of three control subjects and four patients with PD. No significant differences were observed between the number of CR+ neurons in the two subject groups. Sequential double immunostaining for calretinin and tyrosine hydroxylase showed a variable proportion of CR+ neurons among dopaminergic neurons: moderate co-localization was found in catecholaminergic cell group A8 and in the dorsal part of the ventral tegmental area (VTA) and low co-localization in the SNpc, the ventral part of the VTA and the central gray substance. This indicates that calretinin may only protect some dopaminergic neurons against degeneration in PD. Yet, in the SNpc a selective preservation of CR+ dopaminergic neurons was observed, suggesting a neuroprotective role in some dopaminergic cell groups only.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Île-de-France</li></region><settlement><li>Paris</li><li>Paris </li></settlement><orgName><li>Hôpital de la Salpêtrière</li></orgName></list><tree><country name="France"><region name="Île-de-France"><name sortKey="Mouatt Prigent, Annick" sort="Mouatt Prigent, Annick" uniqKey="Mouatt Prigent A" first="Annick" last="Mouatt-Prigent">Annick Mouatt-Prigent</name></region><name sortKey="Agid, Yves" sort="Agid, Yves" uniqKey="Agid Y" first="Yves" last="Agid">Yves Agid</name><name sortKey="Hirsch, Etienne C" sort="Hirsch, Etienne C" uniqKey="Hirsch E" first="Etienne C." last="Hirsch">Etienne C. Hirsch</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002445 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002445 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:28498A4DCDF24F2114BDDFAB7D43925455B0BFA8
|texte= Does the calcium binding protein calretinin protect dopaminergic neurons against degeneration in Parkinson's disease?
}}
| This area was generated with Dilib version V0.6.23. |  |